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Morra, S; Scheipner, L; Baudo, A; Jannello, LMI; de, Angelis, M; Siech, C; Goyal, JA; Touma, N; Tian, Z; Saad, F; Califano, G; Celentano, G; la, Rocca, R; Napolitano, L; Shariat, SF; Ahyai, S; Carmignani, L; de, Cobelli, O; Musi, G; Briganti, A; Chun, FKH; Longo, N; Karakiewicz, PI.
Unmarried status effect on stage at presentation and treatment patterns in primary urethral carcinoma patients.
Urol Oncol. 2024; 42(5):161.e17-161.e23 Doi: 10.1016/j.urolonc.2024.01.022
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Co-authors Med Uni Graz: Ahyai Sascha; Scheipner Lukas
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Abstract:: BACKGROUND: Unmarried status has been associated with advanced stage at presentation and lower treatment dose intensification rates in several urological and non-urological malignancies. However, no previous investigators focused of the association of unmarried status with locally advanced stage (T_3-4N_0-2) at presentation and lower bi-/trimodal therapy rates in primary urethral carcinoma (PUC) patients. To address these knowledge gaps, we relied on the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: Within the SEER database 2000 to 2020, all non-metastatic PUC patients were identified. Logistic regression models (LRMs) tested for differences in stage at presentation and treatment modality in the overall cohort and then in a sex-specific fashion, according to marital status (married vs unmarried). RESULTS: Of all 1,430 non-metastatic PUC patients, 1,004 (70%) were male vs 426 (30%) were female. Of 1,004 male PUC patients, 272 (27%) were unmarried. Of all 426 female PUC patients, 239 (56%) were unmarried. In multivariable LRMs predicting T_3-4N_0-2, unmarried status was independently associated with an increased risk of locally advanced stage at presentation in the overall cohort (odds ratio [OR]:1.31; P = 0.03) and in female patients (OR:1.62; P = 0.02), but not in male PUC patients (P = 0.6). In multivariable LRMs predicting bi-/trimodal therapy, unmarried status was an independent predictor of lower bi-/trimodal therapy rates in the overall cohort (OR:0.73; P = 0.02) and in male patients (OR:0.60; P = 0.007), but not in female PUC patients (P = 0.6). CONCLUSIONS: Unmarried female PUC patients more likely harbored locally advanced stage at presentation. Conversely, unmarried male PUC patients are less likely to benefit from bi-/trimodal therapy.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Male - administration & dosage; Female - administration & dosage; Single Person - administration & dosage; Marital Status - administration & dosage; Carcinoma - administration & dosage; SEER Program - administration & dosage
Find related publications in this database (Keywords): SEER program; Primary urethral carcinoma; Marital status; Unmarried status; Treatment patterns; Sex -specific analysis