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Moik, F; Riedl, JM; Ay, C.
VTE with Amivantamab plus Chemotherapy in NSCLC.
N Engl J Med. 2024; 390(6): 578-579.
Doi: 10.1056/NEJMc2314937
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
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Moik Florian
- Co-authors Med Uni Graz
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Riedl Jakob
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- Abstract:
- To the Editor: In their article on the PAPILLON trial, Zhou et al. (Nov. 30 issue)(1) describe the promising efficacy of amivantamab plus chemotherapy in patients with untreated advanced non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertions. However, highly relevant questions remain open concerning the cardiovascular safety of amivantamab-based therapies, an issue that has been raised in previous studies.(2-4) In particular, a high risk of venous thromboembolism (VTE) was reported in several trials investigating amivantamab in NSCLC as compared with control therapies, with the incidence of VTE ranging from 10% with amivantamab to 21 to . . .
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