Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Vogelsang, TLR; Schmoeckel, E; Topalov, NE; Ganster, F; Mahner, S; Jeschke, U; Vattai, A.
Prognostic Impact of Heat Shock Protein 90 Expression in Women Diagnosed with Cervical Cancer.
Int J Mol Sci. 2024; 25(3): 1571
Doi: 10.3390/ijms25031571
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- Leading authors Med Uni Graz
- Vogelsang Tilman Lauritz Rüdiger
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- Abstract:
- Heat Shock Protein 90 (HSP90), a major molecular chaperone, plays a crucial role in cell function by folding and stabilizing proteins and maintaining proteostasis. This study aimed to elucidate the prognostic impact of HSP90 in cervical cancer. We analyzed HSP90 expression using immunohistochemistry in cervical cancer tissue microarrays from 250 patients. This study investigated correlations between HSP90 expression levels and key clinical outcomes, including overall survival (OS), progression-free survival (PFS), and FIGO classification. The statistical analyses employed included the Kruskal-Wallis-H test, log-rank (Mantel-Cox), and Cox regression. Our findings indicate that high nuclear HSP90 expression is associated with improved OS, while high cytoplasmic HSP90 expression correlates with better PFS and a lower FIGO classification in cervical squamous cell carcinoma patients. These results suggest that HSP90 could serve as a positive prognostic factor in patients diagnosed with cervical squamous cell carcinoma, underlining its potential as a biomarker for patient prognosis and as a target for therapeutic strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Carcinoma, Squamous Cell - pathology
- Prognosis - administration & dosage
- Uterine Cervical Neoplasms - pathology
- HSP90 Heat-Shock Proteins - metabolism
- Molecular Chaperones - administration & dosage
- Find related publications in this database (Keywords)
- HSP90
- chaperone
- cervical cancer
- human papillomavirus
- necroptosis
- programmed cell death