Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Siech, C; Incesu, RB; Morra, S; Scheipner, L; Baudo, A; Jannello, LMI; de, Angelis, M; Goyal, JA; Tian, Z; Saad, F; Shariat, SF; Tilki, D; Longo, N; Carmignani, L; de, Cobelli, O; Ahyai, S; Briganti, A; Mandel, P; Kluth, LA; Chun, FKH; Karakiewicz, PI.
Differences in other-cause mortality in metastatic renal cell carcinoma according to partial vs. radical nephrectomy and age: A propensity score matched study.
Surg Oncol. 2024; 53:102047
Doi: 10.1016/j.suronc.2024.102047
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Ahyai Sascha
- Scheipner Lukas
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- Abstract:
- INTRODUCTION: It is unknown whether the benefit from partial nephrectomy regarding lower other-cause mortality is applicable to older patients with metastatic renal cell carcinoma. MATERIALS AND METHODS: Using Surveillance Epidemiology and End Results database, patients with metastatic renal cell carcinoma, undergoing partial or radical nephrectomy, were stratified according to age (<60, 60-69, and ≥70 years). After propensity score matching, Kaplan-Meier survival analyses and multivariable Cox regression models were used. RESULTS: Of 2,390 patients with metastatic renal cell carcinoma, 885 (37%) were aged <60 years, and 90 (10%) underwent partial nephrectomy; 824 (34%) were aged 60-69 years, and 61 (7%) underwent partial nephrectomy; and 681 (29%) were aged ≥70 years, and 64 (9%) underwent partial nephrectomy. After propensity score matching, in patients aged <60 years, partial nephrectomy was associated with lower other-cause mortality (hazard ratio 0.22; p = 0.02); in patients aged 60-69 years, partial nephrectomy was associated with lower other-cause mortality (hazard ratio 0.38; p = 0.03); but not in patients aged ≥70 years. DISCUSSION: In metastatic renal cell carcinoma, partial nephrectomy is associated with lower other-cause mortality in patients aged <60 years and in patients aged 60-69 years, but not in patients aged ≥70 years. In consequence, consideration of partial nephrectomy might be of great value in younger metastatic renal cell carcinoma patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Carcinoma, Renal Cell - surgery, pathology
- Kidney Neoplasms - surgery, pathology
- Propensity Score - administration & dosage
- SEER Program - administration & dosage
- Nephrectomy - methods
- Find related publications in this database (Keywords)
- Survival
- Partial nephrectomy
- Radical nephrectomy
- SEER
- RCC