Medizinische Universität Graz - Research portal
Selected Publication:
Klein, M; Rosen, A; Graf, A; Lahousen, M; Kucera, H; Pakisch, B; Vavra, N; Beck, A.
Primary fallopian tube carcinoma--a retrospective survey of 51 cases. Austrian Cooperative Study Group for Fallopian Tube Carcinoma.
Arch Gynecol Obstet. 1994; 255(3):141-146
Doi: 10.1007/BF02390941
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- Co-authors Med Uni Graz
- Lahousen Manfred
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- Abstract:
- OBJECTIVE: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I). DESIGN: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were divided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation). RESULTS: Patients of stage 0 had a significantly better prognosis than patients of stage I (p = 0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p = 0.017). CONCLUSION: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality
- Adult - mortality
- Aged - mortality
- Chemotherapy, Adjuvant - mortality
- Combined Modality Therapy - mortality
- Fallopian Tube Neoplasms - mortality
- Fallopian Tubes - pathology
- Female - pathology
- Follow-Up Studies - pathology
- Humans - pathology
- Hysterectomy - pathology
- Middle Aged - pathology
- Neoplasm Invasiveness - pathology
- Neoplasm Staging - pathology
- Radiotherapy, Adjuvant - pathology
- Retrospective Studies - pathology
- Survival Rate - pathology
- Find related publications in this database (Keywords)
- Fallopian Tube Carcinoma
- Stage-0
- Stage-I
- Chemotherapy
- Irradiation