Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Marinho, AL; Kazimi, B; Cwieka, H; Marek, R; Beckmann, F; Willumeit-Römer, R; Moosmann, J; Zeller-Plumhoff, B.
A comparison of deep learning segmentation models for synchrotron radiation based tomograms of biodegradable bone implants
FRONT PHYS-LAUSANNE. 2024; 12: 1257512
Doi: 10.3389/fphy.2024.1257512
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Marek Romy Linda
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- Abstract:
- Introduction: Synchrotron radiation micro-computed tomography (SR mu CT) has been used as a non-invasive technique to examine the microstructure and tissue integration of biodegradable bone implants. To be able to characterize parameters regarding the disintegration and osseointegration of such materials quantitatively, the three-dimensional (3D) image data provided by SR mu CT needs to be processed by means of semantic segmentation. However, accurate image segmentation is challenging using traditional automated techniques. This study investigates the effectiveness of deep learning approaches for semantic segmentation of SR mu CT volumes of Mg-based implants in sheep bone ex vivo.Methodology: For this purpose different convolutional neural networks (CNNs), including U-Net, HR-Net, U-2-Net, from the TomoSeg framework, the Scaled U-Net framework, and 2D/3D U-Net from the nnU-Net framework were trained and validated. The image data used in this work was part of a previous study where biodegradable screws were surgically implanted in sheep tibiae and imaged using SR mu CT after different healing periods. The comparative analysis of CNN models considers their performance in semantic segmentation and subsequent calculation of degradation and osseointegration parameters. The models' performance is evaluated using the intersection over union (IoU) metric, and their generalization ability is tested on unseen datasets.Results and discussion: This work shows that the 2D nnU-Net achieves better generalization performance, with the degradation layer being the most challenging label to segment for all models.
- Find related publications in this database (Keywords)
- synchrotron radiation micro-computed tomography
- biodegradable materials
- magnesium-based alloys
- semantic segmentation
- convolutional neural networks