Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fritsch, P; Cvirn, G; Cimenti, C; Baier, K; Gallistl, S; Koestenberger, M; Roschitz, B; Leschnik, B; Muntean, W.
Thrombin generation in factor VIII-depleted neonatal plasma: nearly normal because of physiologically low antithrombin and tissue factor pathway inhibitor.
J Thromb Haemost. 2006; 4(5): 1071-1077.
Doi: 10.1111/j.1538-7836.2006.01947.x
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- Führende Autor*innen der Med Uni Graz
- Fritsch Peter
- Muntean Eugen
- Co-Autor*innen der Med Uni Graz
- Acham-Roschitz Birgit
- Cimenti Christina
- Cvirn Gerhard
- Gallistl Siegfried
- Koestenberger Martin
- Leschnik Bettina
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- Abstract:
- Background: Bleeding in hemophilic neonates has a low incidence. A possible explanation for this could be the peculiarities of the neonatal hemostatic system, especially low levels of the inhibitors tissue factor pathway inhibitor (TFPI) and antithrombin (AT). Objective: We investigated the influence of an elevation of these inhibitors to adult levels oil the thrombin generation (TG) in normal neonatal plasma and factor (F) VIII-depleted neonatal plasma by means of incubation with anti-FVIII-antibodies. Patients/methods: TG was measured after activation with low amounts of tissue factor (TF) by using Calibrated Automated Thrombography. Results: TG in FVIII-depleted neonatal plasma was nearly as high as in normal neonatal plasma. TG decreased after elevation of AT in both neonatal plasmas. After elevation of TFPI TG decreased much more in FVIII-depleted neonatal plasma than in normal neonatal plasma. After elevation of both inhibitors their synergistic effect led to a stronger decrease of TG in FVIII-depleted neonatal plasma. TG measured in plasma of one hemophilic newborn showed the same pattern as in FVIII-depleted neonatal plasma. Conclusion: Our observation provides a biochemical basis for the rare bleeding in hemophilic neonates and shows the important role of the natural inhibitors in the hemostatic system of hemophilic patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antithrombins - metabolism
- Factor VIII - metabolism
- Humans - metabolism
- Infant, Newborn - metabolism
- Lipoproteins - blood
- Plasma - blood
- Research Support, Non-U.S. Gov't - blood
- Thrombin - biosynthesis
- Find related publications in this database (Keywords)
- antithrombin
- hemophilia
- newborn
- thrombin generation
- tissue factor
- tissue factor pathway inhibitor