Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bele, U; Bratus, D.
Dextranomer-Hyaluronic Acid and Polyacrylate-Polyalcohol Copolymer are Equally Efficient for Endoscopic Treatment of Vesicoureteral Reflux in Children.
Urol J. 2019; 16(4): 361-365.
Doi: 10.22037/uj.v0i0.4462
Web of Science
PubMed
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FullText_MUG
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- Bele Uros
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- Abstract:
- PURPOSE: To compare the efficacy of two bulking agents, Dextranomer-Hyaluronic Acid (DxHA) and Polyacrylate-Polyalcohol Copolymer (PPC) used for endoscopic treatment of vesicoureteral reflux (VUR). MATERIALS AND METHODS: We endoscopically treated 125 patients (89 girls and 36 boys) diagnosed with VUR grades I-V, comprising a total of 174 refluxing ureters (RUs). Patients were categorized into two groups, 99 (56,9%) RUs were treated with DxHA (Group 1) and 75 (43,1%) RUs with PPC (Group 2). RUs treated with both bulking agents were excluded. The success of treatment was evaluated with postoperative VCUG at 3- and 12-months after the endoscopic procedure, only complete resolution of VUR was considered as treatment success. Data was collected and analyzed retrospectively. Statistical calculations were performed using the Chi-square test. RESULTS: After a single injection 80,0% (60/75) and 68,7% (68/99 RUs) of RUs resolved completely when treated with PPC and DxHA, respectively (P = .094). A second injection of PPC healed another 10 RUs (total 93,3%), whereas DxHA resolved additional 16 RUs (total 84,8%) (P = .097). A third injection was needed for 1 RU, treated with PPC and another 3 RUs with DxHA. Twelve months post-operatively, we achieved a total resolution rate of 94,7% (71/75 RUs) with PPC, while DxHA successfully treated 87,9% (87/99) of RUs (P = .125). CONCLUSIONS: DxHA and PPC showed no statistically significant differences neither in the number of injections needed nor in the total success rate after 12 months of follow-up.
- Find related publications in this database (using NLM MeSH Indexing)
- Acrylic Resins - therapeutic use
- Child, Preschool - administration & dosage
- Cystoscopy - administration & dosage
- Dextrans - therapeutic use
- Female - administration & dosage
- Humans - administration & dosage
- Hyaluronic Acid - therapeutic use
- Male - administration & dosage
- Polymers - therapeutic use
- Retrospective Studies - administration & dosage
- Treatment Outcome - administration & dosage
- Vesico-Ureteral Reflux - drug therapy, surgery
- Find related publications in this database (Keywords)
- Deflux
- dextranomer hyaluronic acid
- endoscopic injection
- polyacrylate polyalcohol copolymer
- Vantris
- vesicoureteral reflux