Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schellnegger, M; Hofmann, E; Carnieletto, M; Kamolz, LP.
Unlocking longevity: the role of telomeres and its targeting interventions.
Front Aging. 2024; 5: 1339317
Doi: 10.3389/fragi.2024.1339317
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- Leading authors Med Uni Graz
- Schellnegger Marlies
- Co-authors Med Uni Graz
- Carnieletto Martina
- Hofmann Elisabeth
- Kamolz Lars-Peter
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- Abstract:
- Average life expectancy has been steadily increasing in developed countries worldwide. These demographic changes are associated with an ever-growing social and economic strain to healthcare systems as well as society. The aging process typically manifests as a decline in physiological and cognitive functions, accompanied by a rise in chronic diseases. Consequently, strategies that both mitigate age-related diseases and promote healthy aging are urgently needed. Telomere attrition, characterized by the shortening of telomeres with each cell division, paradoxically serves as both a protective mechanism and a contributor to tissue degeneration and age-related ailments. Based on the essential role of telomere biology in aging, research efforts aim to develop approaches designed to counteract telomere attrition, aiming to delay or reduce age-related diseases. In this review, telomere biology and its role in aging and age-related diseases is summarized along with recent approaches to interfere with telomere shortening aiming at well- and healthy-aging as well as longevity. As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins.
- Find related publications in this database (Keywords)
- telomere length
- telomerase
- longevity
- interventions
- oxidative stress
- inflammation
- telomerase activators