Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Derks, W; Rode, J; Collin, S; Rost, F; Heinke, P; Hariharan, A; Pickel, L; Simonova, I; Lázár, E; Graham, E; Jashari, R; Andrä, M; Jeppsson, A; Salehpour, M; Alkass, K; Druid, H; Kyriakopoulos, CP; Taleb, I; Shankar, TS; Selzman, CH; Sadek, H; Jovinge, S; Brusch, L; Frisén, J; Drakos, S; Bergmann, O.
A latent cardiomyocyte regeneration potential in human heart disease.
bioRxiv. 2023;
Doi: 10.1101/2023.09.14.557681
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- Autor*innen der Med Uni Graz:
- Andrä Michaela
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- Abstract:
- Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective 14C birth dating we analyzed cardiomyocyte renewal in patients with end-stage heart failure. We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18-50 times lower compared to the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.