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SHR Neuro Cancer Cardio Lipid Metab Microb

Chromy, D; Sadoghi, B; Gasslitter, I; Skocic, M; Okoro, A; Grabmeier-Pfistershammer, K; Willinger, B; Weninger, W; Öllinger, A; Sarcletti, M; Stary, G; Bauer, WM.
Asymptomatic lymphogranuloma venereum is commonly found among men who have sex with men in Austria.
J Dtsch Dermatol Ges. 2024; Doi: 10.1111/ddg.15329
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Sadoghi Birgit
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Abstract:: BACKGROUND AND OBJECTIVES: Serovar L1-L3 of Chlamydia trachomatis (CT) causes lymphogranuloma venereum (LGV). A surge in LGV-cases has been observed among HIV-positive men who have sex with men (MSM). Discrimination between LGV and non-LGV is pivotal since it has major treatment implications. Here, we aimed to determine the prevalence and characteristics of LGV among CT-infections. PATIENTS AND METHODS: All CT-positive results from 04/2014-12/2021 at the four largest Austrian HIV and STI clinics were evaluated. Disease characteristics and patient demographics were analyzed. RESULTS: Overall, n = 2,083 infections of CT were documented in n = 1,479 individual patients: median age was 31.4 years, 81% were male, 59% MSM, 44% HIV-positive, 13% on HIV pre-exposure-prophylaxis. Available serovar analyses (61% [1,258/2,083]) showed L1-L3 in 15% (192/1,258). Considering only MSM with rectal CT-infection, LGV accounted for 23% (101/439). Cases of LGV vs. other CT-infections were primarily MSM (92% [177/192] vs. 62% [1,179/1,891], p < 0.001), more often HIV-positive (64% [116/180] vs. 46% [631/1,376]; p < 0.001) and had frequently concomitant syphilis infection (18% [32/180] vs. 7% [52/749]; p < 0.001). LGV commonly manifested as proctitis (38% [72/192]) whereas 45% (87/192) were asymptomatic. CONCLUSIONS: Lymphogranuloma venereum accounted for 23% of rectal CT-infections in MSM. Furthermore, 45% of all LGV-cases were asymptomatic. In the absence of CT-serovar analysis, a high LGV prevalence should be considered in risk-populations and guide empiric treatment selection.
Find related publications in this database (Keywords): Chlamydia trachomatis; lymphogranuloma venereum; men who have sex with men (MSM); proctitis