Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hu, R; Kagele, DA; Huffaker, TB; Runtsch, MC; Alexander, M; Liu, J; Bake, E; Su, W; Williams, MA; Rao, DS; Möller, T; Garden, GA; Round, JL; O'Connell, RM.
miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.
Immunity. 2014; 41(4): 605-19.
Doi: 10.1016/j.immuni.2014.09.015
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- Co-Autor*innen der Med Uni Graz
- Runtsch Marah
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- Abstract:
- Chronic inflammation is a contributing factor to most life-shortening human diseases. However, the molecular and cellular mechanisms that sustain chronic inflammatory responses remain poorly understood, making it difficult to treat this deleterious condition. Using a mouse model of age-dependent inflammation that results from a deficiency in miR-146a, we demonstrate that miR-155 contributed to the progressive inflammatory disease that emerged as Mir146a(-/-) mice grew older. Upon analyzing lymphocytes from inflamed versus healthy middle-aged mice, we found elevated numbers of T follicular helper (Tfh) cells, germinal center (GC) B cells, and autoantibodies, all occurring in a miR-155-dependent manner. Further, Cd4-cre Mir155(fl/fl) mice were generated and demonstrated that miR-155 functions in T cells, in addition to its established role in B cells, to promote humoral immunity in a variety of contexts. Taken together, our study discovers that miR-146a and miR-155 counterregulate Tfh cell development that drives aberrant GC reactions during chronic inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adoptive Transfer - administration & dosage
- Animals - administration & dosage
- Autoantibodies - biosynthesis, immunology
- B-Lymphocytes - immunology
- CD4 Antigens - biosynthesis
- Cell Differentiation - immunology
- Disease Models, Animal - administration & dosage
- Fos-Related Antigen-2 - genetics
- Germinal Center - cytology, immunology
- Immunity, Humoral - administration & dosage
- Inflammation - immunology
- Lymphocyte Activation - immunology
- Mice - administration & dosage
- Mice, Inbred C57BL - administration & dosage
- Mice, Knockout - administration & dosage
- MicroRNAs - genetics, immunology
- RNA Interference - administration & dosage
- RNA, Small Interfering - administration & dosage
- T-Lymphocytes, Helper-Inducer - immunology