Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Heijman, J; Voigt, N; Nattel, S; Dobrev, D.
Calcium handling and atrial fibrillation.
Wien Med Wochenschr. 2012; 162(13-14): 287-91.
Doi: 10.1007/s10354-012-0109-9
PubMed
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- Leading authors Med Uni Graz
- Heijman Jordi
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- Abstract:
- Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca(2+) handling plays a critical role in the induction and maintenance of AF, contributing to ectopic activity, AF-maintaining reentry circuits and related prothrombotic atrial hypocontractility. The AF-specific Ca(2+)-handling abnormalities may constitute viable therapeutic approaches to treat AF. Here, we review the causes, consequences, and therapeutic implications of altered atrial Ca(2+) handling for AF pathophysiology.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Anti-Arrhythmia Agents - therapeutic use
- Atrial Fibrillation - drug therapy, physiopathology
- Atrial Premature Complexes - drug therapy, physiopathology
- Calcium - metabolism
- Calcium Channels, L-Type - drug effects, physiology
- Electrocardiography - drug effects
- Heart Atria - drug effects, physiopathology
- Humans - administration & dosage
- Muscle Cells - drug effects, physiology
- Myocardial Contraction - drug effects, physiology
- Ryanodine Receptor Calcium Release Channel - drug effects, physiology
- Sarcoplasmic Reticulum - drug effects, physiology
- Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology
- Tachycardia, Atrioventricular Nodal Reentry - drug therapy, physiopathology
- Thrombosis - drug therapy, physiopathology