Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Abu-Taha, IH; Heijman, J; Feng, Y; Vettel, C; Dobrev, D; Wieland, T.
Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update
LAB INVEST. 2018; 98(2): 190-197.
Doi: 10.1038/labinvest.2017.103
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Heijman Jordi
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- Abstract:
- Heterotrimeric G proteins are pivotal mediators of cellular signal transduction in eukaryotic cells and abnormal G-protein signaling plays an important role in numerous diseases. During the last two decades it has become evident that the activation status of heterotrimeric G proteins is both highly localized and strongly regulated by a number of factors, including a receptor-independent activation pathway of heterotrimeric G proteins that does not involve the classical GDP/GTP exchange and relies on nucleoside diphosphate kinases (NDPKs). NDPKs are NTP/NDP transphosphorylases encoded by the nme/nm23 genes that are involved in a variety of cellular events such as proliferation, migration, and apoptosis. They therefore contribute, for example, to tumor metastasis, angiogenesis, retinopathy, and heart failure. Interestingly, NDPKs are translocated and/or upregulated in human heart failure. Here we describe recent advances in the current understanding of NDPK functions and how they have an impact on local regulation of G-protein signaling.