Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Heijman, J; Dewenter, M; El-Armouche, A; Dobrev, D.
Function and regulation of serine/threonine phosphatases in the healthy and diseased heart
J MOL CELL CARDIOL. 2013; 64: 90-98. Doi: 10.1016/j.yjmcc.2013.09.006
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Heijman Jordi
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Protein phosphorylation is a major control mechanism of a wide range of physiological processes and plays an important role in cardiac pathophysiology. Serine/threonine protein phosphatases control the dephosphorylation of a variety of cardiac proteins, thereby fine-tuning cardiac electrophysiology and function. Specificity of protein phosphatases type-1 and type-2A is achieved by multiprotein complexes that target the catalytic subunits to specific subcellular domains. Here, we describe the composition, regulation and target substrates of serine/threonine phosphatases in the heart. In addition, we provide an overview of pharmacological tools and genetic models to study the role of cardiac phosphatases. Finally, we review the role of protein phosphatases in the diseased heart, particularly in ventricular arrhythmias and atrial fibrillation and discuss their role as potential therapeutic targets. (C) 2013 Elsevier Ltd. All rights reserved.
Find related publications in this database (Keywords): Dephosphorylation; Protein phosphatases; Heart failure; Atrial fibrillation