Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Heijman, J; Voigt, N; Carlsson, LG; Dobrev, D.
Cardiac safety assays
CURR OPIN PHARMACOL. 2014; 15: 16-21.
Doi: 10.1016/j.coph.2013.11.004
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Heijman Jordi
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- Abstract:
- Cardiac safety, including the risk of drug-induced `torsades de pointes' (TdP) arrhythmia, is a major concern in the development, approval and prescription of new drugs. Assessment of surrogate markers of TdP-risk, such as QTinterval prolongation or inhibition of the rapid delayed-rectifier K+-current ('Kr) encoded by the human ether-a-go-go-related gene (hERG), is therefore required before drug approval. Here, we review some methodologies employed to assess proarrhythmia liability of drugs, discuss the challenges involved in this process, and highlight promising novel cardiac-safety assays.