Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dąbrowska, A; Grubba, M; Balihodzic, A; Szot, O; Sobocki, BK; Perdyan, A.
The Role of Regulatory T Cells in Cancer Treatment Resistance.
Int J Mol Sci. 2023; 24(18):
Doi: 10.3390/ijms241814114
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Balihodzic Amar
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- Abstract:
- Despite tremendous progress in cancer treatment in recent years, treatment resistance is still a major challenge for a great number of patients. One of the main causes is regulatory T lymphocytes (Tregs), which suppress excessive inflammatory responses via the secretion of immunosuppressive cytokines and upregulate the immune checkpoints. Their abundance causes an immunosuppressive reprogramming of the tumor environment, which is ideal for tumor growth and drug inefficiency. Hence, regiments that can regain tumor immunogenicity are a promising strategy to overcome Tregs-mediated drug resistance. However, to develop effective therapeutic regimens, it is essential to understand the molecular mechanisms of Treg-mediated resistance. In this article, we gathered a comprehensive summary of the current knowledge on molecular mechanisms and the role of Tregs in cancer treatment resistance, including cancer immunotherapy, targeted therapy, chemotherapy, and radiotherapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- T-Lymphocytes, Regulatory - administration & dosage
- Immunotherapy - administration & dosage
- Cytokines - administration & dosage
- Immunosuppressive Agents - administration & dosage
- Radiation Oncology - administration & dosage
- Neoplasms - therapy
- Find related publications in this database (Keywords)
- regulatory T cell
- resistance mechanisms
- immunotherapy
- chemotherapy
- radiotherapy