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SHR Neuro Cancer Cardio Lipid Metab Microb

Edlinger, L.
In Vivo Modeling of Leukemia by Murine Stem Cell Transplantation.
Methods Mol Biol. 2024; 2773: 1-7. Doi: 10.1007/978-1-0716-3714-2_1
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Leading authors Med Uni Graz: Edlinger Leo
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Abstract:: Murine stem cell transplantation is a well-established method for the in vivo study of leukemic pathophysiology. Adoptive transfer of murine leukemic cells into lethally irradiated recipient mice leads to reconstitution of the hematopoietic system with malignant cells and eventually to leukemic progression in the recipient mice. Here, we describe the detailed protocol of the production of retroviral particles carrying the leukemic oncogene of interest as well as the isolation, retroviral transduction, and adoptive transfer of murine bone marrow cells.
Find related publications in this database (using NLM MeSH Indexing): Animals - administration & dosage; Mice - administration & dosage; Hematopoietic Stem Cell Transplantation - administration & dosage; Stem Cell Transplantation - administration & dosage; Leukemia - genetics, therapy; Adoptive Transfer - administration & dosage; Bone Marrow Cells - administration & dosage