Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sengupta, J; Kroneis, T; Boddy, AM; Roy, R; Sarkar, A; Sarkar, D; Ghosh, D; Huppertz, B.
Sperm intrusion into the implantation-stage blastocyst and its potential biological significance.
Evol Med Public Health. 2024; 12(1): 1-6.
Doi: 10.1093/emph/eoad043
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- Führende Autor*innen der Med Uni Graz
- Huppertz Berthold
- Kroneis Thomas
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- Abstract:
- The human embryo derives from fusion of oocyte and sperm, undergoes growth and differentiation, resulting in a blastocyst. To initiate implantation, the blastocyst hatches from the zona pellucida, allowing access from external inputs. Modelling of uterine sperm distribution indicates that 200-5000 sperm cells may reach the implantation-stage blastocyst following natural coitus. We show ultrastructural evidence of sperm cells intruding into trophectoderm cells of zona-free blastocysts obtained from the uterus of rhesus monkeys. Interaction between additional sperm and zona-free blastocyst could be an evolutionary feature yielding adaptive processes influencing the developmental fate of embryos. This process bears potential implications in pregnancy success, sperm competition and human health.
- Find related publications in this database (Keywords)
- zona-free blastocyst
- mid-luteal phase
- sperm competition
- trophectoderm
- ultrastructure
- microchimerism