Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seebacher, W; Hoffelner, M; Belaj, F; Pirker, T; Alajlani, M; Bauer, R; Pferschy-Wenzig, EM; Saf, R; Weis, R.
Formation of 5-Aminomethyl-2,3-dihydropyridine-4(1H)-ones from 4-Amino-tetrahydropyridinylidene Salts.
Molecules. 2023; 28(19):
Doi: 10.3390/molecules28196869
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- Co-Autor*innen der Med Uni Graz
- Pirker Teresa Marie
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- Abstract:
- Various 4-aminotetrahydropyridinylidene salts were treated with aldehydes in an alkaline medium. Their conversion to 5-substituted β-hydroxyketones in a one-step reaction succeeded only with an aliphatic aldehyde. Instead, aromatic aldehydes gave 5-substituted β-aminoketones or a single δ-diketone. The new compounds were characterized using spectroscopic methods and a single crystal structure analysis. Some of them showed anticancer and antibacterial properties.
- Find related publications in this database (Keywords)
- antibacterial
- anticancer activity
- dihydropyridin-4(1H)-ones
- tetrahydropyridinylidene salts