Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stauber, RE; Paar, M; Balazs, I; Horvath, A; Feldbacher, N; Posch, A; Rainer, F; Stadlbauer, V; Oettl, K.
Effect of albumin infusion on oxidative albumin modification and albumin binding capacity in chronic liver failure.
Basic Clin Pharmacol Toxicol. 2024; 134(3):375-384
Doi: 10.1111/bcpt.13973
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Stauber Rudolf
- Co-Autor*innen der Med Uni Graz
- Balazs Irina
- Feldbacher Nicole
- Horvath Angela
- Öttl Karl
- Paar Margret
- Posch Andreas
- Rainer Florian
- Stadlbauer-Köllner Vanessa
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Oxidative albumin modification and impaired albumin binding function have been described both in chronic liver failure and for therapeutic albumin solutions. The aim of the present study was to evaluate the effect of albumin infusion on redox state and binding function of circulating albumin. We studied 20 patients with cirrhosis who routinely received albumin infusions for prevention of post-paracentesis circulatory dysfunction or treatment of hepatorenal syndrome. We measured albumin fractions by redox state of cysteine-34 and albumin binding properties using dansylsarcosine as site II ligand. Therapeutic albumin solutions showed high contents of human nonmercaptalbumin-1 and human nonmercaptalbumin-2, exceeding the respective values in our patients with decompensated cirrhosis. An initial protocol for the first nine patients sampled at baseline, 24 h and 48 h after albumin infusion revealed no significant changes of oxidized albumin species or albumin binding properties. However, a modified protocol for the remaining 11 patients sampled at baseline, <1 h after and 24 h after albumin infusion revealed short-lived changes of oxidized albumin species while no changes in albumin binding properties were observed. In conclusion, therapeutic albumin infusion transiently changed albumin redox state but did not improve binding function of circulating albumin in chronic liver failure.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- End Stage Liver Disease - drug therapy
- Serum Albumin - administration & dosage
- Liver Cirrhosis - drug therapy, metabolism
- Oxidative Stress - administration & dosage
- Oxidation-Reduction - administration & dosage
- Find related publications in this database (Keywords)
- albumin binding capacity
- human mercaptalbumin
- human nonmercaptalbumin-1
- human nonmercaptalbumin-2
- neutrophil function