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SHR Neuro Cancer Cardio Lipid Metab Microb

Geier, J; Schubert, S; Rieker-Schwienbacher, J; Brans, R; Weisshaar, E; Kränke, B; Brockow, K; Ruёff, F; Recke, A; Uter, W, , IVDK.
Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021.
Contact Dermatitis. 2023; Doi: 10.1111/cod.14493
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Kränke Birger
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Abstract:: BACKGROUND: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are patch tested as screening mixtures in the baseline series. OBJECTIVE: To describe the time trends of reaction frequencies to both FMs as well as to their components in FM-positive patients. METHODS: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2012-2021. RESULTS: Positive reactions to FM I (FM II) declined from 9.1% (4.7%) in 2012 to 4.6% (3.0%) in 2021. Full breakdown tests were performed in 24% (FM I) and 31% (FM II), respectively, of the mix-positive patients. From this data, frequencies of sensitization to the 14 single fragrances of FM I and FM II were calculated. For the majority, a decline was noted from 2012/2013 to 2020/2021, for oakmoss absolute 1.9%-0.8% and for HICC 1.8%-0.9%. CONCLUSION: EU Commission Regulation 2017/1410 was an effective measure. However, our data have some limitations, possibly causing underestimation of sensitization frequencies to fragrances.
Find related publications in this database (Keywords): atranol; chloroatranol; clinical epidemiology; contact allergy; Evernia prunastri; fragrance mix I; fragrance mix II; hydroxyisohexyl 3-cyclohexene carboxaldehyde; patch testing