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SHR Neuro Cancer Cardio Lipid Metab Microb

Guertl, B; Leuschner, I; Harms, D; Hoefler, G.
Genetic clonality is a feature unifying nephroblastomas regardless of the variety of morphological subtypes.
Virchows Arch. 2006; 449(2):171-174 Doi: 10.1007/s00428-006-0225-2
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Leading authors Med Uni Graz: Gürtl-Lackner Barbara
Co-authors Med Uni Graz: Höfler Gerald
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Abstract:: Nephroblastomas are embryonal tumors exhibiting a wide variety of different morphological features and genetic changes. Some of the genetic aberrations were associated with a certain histological subtype. It is generally assumed that nephroblastomas develop as subclonal proliferations from nephrogenic rests. However, so far, a very limited amount of tumors from only part of the morphological spectrum of nephroblastomas was investigated. We therefore investigated the clonality of 45 tumors of all different histological subtypes. The number of each subtype was in accordance with the percentage of occurrence of the respective subtype. We analyzed a highly polymorphic locus of the human androgen receptor gene for nonrandom X-inactivation of genomic DNA using a methylation-sensitive restriction enzyme. Data were obtained for 39 tumors. Eighteen of the tumors included were noninformative in the genetic locus examined, the remaining 21 tumors were monoclonal regardless of the histological subtype. Our findings therefore support the hypothesis that Wilms' tumors are monoclonal proliferations despite their large variety of morphological features.
Find related publications in this database (using NLM MeSH Indexing): Humans -; Kidney Neoplasms - genetics Kidney Neoplasms - pathology; Receptors, Androgen - genetics; Wilms Tumor - genetics Wilms Tumor - pathology
Find related publications in this database (Keywords): nephroblastoma; HUMARA analysis; clonality