Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Disanto, G; Adiutori, R; Dobson, R; Martinelli, V; Dalla, Costa, G; Runia, T; Evdoshenko, E; Thouvenot, E; Trojano, M; Norgren, N; Teunissen, C; Kappos, L; Giovannoni, G; Kuhle, J, , International, Clinically, Isolated, Syndrome, Study, Group.
Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome.
J Neurol Neurosurg Psychiatry. 2016; 87(2):126-9
Doi: 10.1136/jnnp-2014-309690
Web of Science
PubMed
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- Study Group Mitglieder der Med Uni Graz:
- Enzinger Christian
- Fuchs Siegrid
- Khalil Michael
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- Abstract:
- BACKGROUND: Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. METHODS: We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. RESULTS: NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p = 1.5 × 10(-5) and OR = 7.03; 95% CI 2.85 to 17.34; p = 2.3 × 10(-5), respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR = 2.36; 95% CI 1.21 to 4.59; p = 0.011), gadolinium-enhancing lesions (OR = 2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR = 2.54; 95% CI 1.21 to 5.31; p = 0.013) at CIS diagnosis. CONCLUSIONS: If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Axons - pathology
- Biomarkers - administration & dosage
- Demyelinating Diseases - pathology
- Disease Progression - administration & dosage
- Female - administration & dosage
- Follow-Up Studies - administration & dosage
- Humans - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Male - administration & dosage
- Multiple Sclerosis - blood
- Neurofilament Proteins - blood
- Predictive Value of Tests - administration & dosage