Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kelsoe, J; Ou, A; Rosenthal, S; Adli, M; Akiyama, K; Akula, N; Alda, M; Amare, AT; Ardau, R; Arias, B; Aubry, JM; Backlund, L; Banzato, C; Bauer, M; Baune, B; Bellivier, F; Benabarre, A; Bengesser, S; Abesh, B; Biernacka, J; Bui, E; Cervantes, P; Chen, GB; Chen, HC; Chillotti, C; Cichon, S; Clark, S; Colom, F; Cousins, D; Cruceanu, C; Czerski, P; Dantas, C; Dayer, A; Degenhardt, F; DePaulo, JR; Etain, B; Falkai, P; Fellendorf, F; Ferensztajn-Rochowiak, E; Forstner, AJ; Frisen, L; Frye, M; Fullerton, J; Gard, S; Garnham, J; Goes, F; Grigoroiu-Serbanescu, M; Grof, P; Gruber, O; Hashimoto, R; Hauser, J; Heilbronner, U; Herms, S; Hoffmann, P; Hofmann, A; Hou, L; Jamain, S; Jiménez, E; Kahn, JP; Kassem, L; Kato, T; Kittel-Schneider, S; König, B; Kuo, PH; Kusumi, I; Dalkner, N; Laje, G; Landén, M; Lavebratt, C; Leboyer, M; Leckband, S; Jaramillo, CL; MacQueen, G; Maj, M; Manchia, M; Marie-Claire, C; Martinsson, L; Mattheisen, M; McCarthy, M; McElroy, S; McMahon, F; Mitchell, P; Mitjans, M; Mondimore, F; Monteleone, P; Nievergelt, C; Nöthen, M; Novak, T; Osby, U; Ozaki, N; Papiol, S; Perlis, R; Pfennig, A; Potash, J; Reich-Erkelenz, D; Reif, A; Reininghaus, E; Rietschel, M; Rouleau, G; Rybakowski, JK; Schalling, M; Schofield, P; Schubert, KO; Schulze, T; Schweizer, B; Seemüller, F; Severino, G; Shekhtman, T; Shilling, P; Shimoda, K; Simhandl, C; Slaney, C; Squassina, A; Stamm, T; Stopkova, P; Tighe, S; Tortorella, A; Turecki, G; Vieta, E; Volkert, J; Witt, S; Wray, N; Wright, A; Young, T; Zandi, P; Zompo, MD.
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
Res Sq. 2023;
Doi: 10.21203/rs.3.rs-3258813/v1
[OPEN ACCESS]
PubMed
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- Autor*innen der Med Uni Graz:
- Bengesser Susanne
- Dalkner Nina
- Fellendorf Frederike
- Reininghaus Eva
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- Abstract:
- Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.