Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Amare, A; Thalamuthu, A; Schubert, KO; Fullerton, J; Ahmed, M; Hartmann, S; Papiol, S; Heilbronner, U; Degenhardt, F; Tekola-Ayele, F; Hou, L; Hsu, YH; Shekhtman, T; Adli, M; Akula, N; Akiyama, K; Ardau, R; Arias, B; Aubry, JM; Backlund, L; Bhattacharjee, AK; Bellivier, F; Benabarre, A; Bengesser, S; Biernacka, J; Birner, A; Marie-Claire, C; Cervantes, P; Chen, HC; Chillotti, C; Cichon, S; Cruceanu, C; Czerski, P; Dalkner, N; Del, Zompo, M; DePaulo, JR; Etain, B; Jamain, S; Falkai, P; Forstner, AJ; Frisén, L; Frye, M; Gard, S; Garnham, J; Goes, F; Grigoroiu-Serbanescu, M; Fallgatter, A; Stegmaier, S; Ethofer, T; Biere, S; Petrova, K; Schuster, C; Adorjan, K; Budde, M; Heilbronner, M; Kalman, J; Oraki, Kohshour, M; Reich-Erkelenz, D; Schaupp, S; Schulte, E; Senner, F; Vogl, T; Anghelescu, IG; Arolt, V; Dannlowski, U; Dietrich, DE; Figge, C; Jäger, M; Lang, F; Juckel, G; Spitzer, C; Reimer, J; Schmauß, M; Schmitt, A; Konrad, C; von, Hagen, M; Wiltfang, J; Zimmermann, J; Andlauer, T; Fischer, A; Bermpohl, F; Kraft, V; Matura, S; Gryaznova, A; Falkenberg, I; Yildiz, C; Kircher, T; Schmidt, J; Koch, M; Gade, K; Trost, S; Haußleiter, I; Lambert, M; Rohenkohl, AC; Kraft, V; Grof, P; Hashimoto, R; Hauser, J; Herms, S; Hoffmann, P; Jiménez, E; Kahn, JP; Kassem, L; Kuo, PH; Kato, T; Kelsoe, J; Kittel-Schneider, S; Ferensztajn-Rochowiak, E; König, B; Kusumi, I; Laje, G; Landén, M; Lavebratt, C; Leboyer, M; Leckband, SG; Tortorella, A; Manchia, M; Martinsson, L; McCarthy, M; McElroy, SL; Colom, F; Mitjans, M; Mondimore, F; Monteleone, P; Nievergelt, C; Nöthen, M; Novak, T; O'Donovan, C; Ozaki, N; Pfennig, A; Pisanu, C; Potash, J; Reif, A; Reininghaus, E; Rouleau, G; Rybakowski, JK; Schalling, M; Schofield, P; Schweizer, BW; Severino, G; Shilling, PD; Shimoda, K; Simhandl, C; Slaney, C; Squassina, A; Stamm, T; Stopkova, P; Maj, M; Turecki, G; Vieta, E; Veeh, J; Witt, S; Wright, A; Zandi, P; Mitchell, P; Bauer, M; Alda, M; Rietschel, M; McMahon, F; Schulze, TG; Millischer, V; Clark, S; Baune, B.
Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
Res Sq. 2023;
Doi: 10.21203/rs.3.rs-2580252/v1
[OPEN ACCESS]
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Dalkner Nina
- Reininghaus Eva
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������.