Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Burbage, M; Keppler, SJ.
Shaping the humoral immune response: Actin regulators modulate antigen presentation and influence B-T interactions.
Mol Immunol. 2018; 101: 370-376.
Doi: 10.1016/j.molimm.2018.07.026
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Keppler Selina Jessica
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- Abstract:
- B cells are an integral part of the adaptive immune system. During an immune response, the actin cytoskeleton plays a central role in regulating B cell antigen uptake, polarization and presentation as well as B cell migration and interaction with T cells. Genetic defects affecting actin regulators can result in reduced B cell activation, limited antibody production and hence cause disease. In this review, we discuss molecular mechanisms of actin regulation and their involvement in antigen polarisation and presentation, as well as their role in influencing interactions between B and T cells. Improved understanding of these mechanisms is necessary for the development of new therapeutic options modulating humoral immune responses.
- Find related publications in this database (using NLM MeSH Indexing)
- Actins - metabolism
- Animals - administration & dosage
- Antigen Presentation - immunology
- B-Lymphocytes - immunology
- Germinal Center - metabolism
- Humans - administration & dosage
- Immunity, Humoral - administration & dosage
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- B lymphocytes
- Antigen presentation
- B-T interactions
- Actin cytoskeleton
- Germinal centers