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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Keppler, SJ; Goess, MC; Heinze, JM.
The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses.
Front Immunol. 2021; 12: 670290
Doi: 10.3389/fimmu.2021.670290
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- Leading authors Med Uni Graz
- Keppler Selina Jessica
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- Abstract:
- Humoral immunity is mainly mediated by a B cell population highly specialized to synthesize and secrete large quantities of antibodies - the antibody-secreting cells (ASC). In the gastrointestinal environment, a mixture of foreign antigens from the diet, commensal microbiota as well as occasional harmful pathogens lead to a constant differentiation of B cells into ASC. Due to this permanent immune response, more than 80% of mammalian ASC reside in the gut, of which most express immunoglobulin A (IgA). IgA antibodies contribute to intestinal homeostasis and can mediate protective immunity. Recent evidence points at a role for gut-derived ASC in modulating immune responses also outside of mucosal tissues. We here summarize recent evidence for wandering ASC, their antibodies and their involvement in systemic immune responses.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Chemotaxis, Leukocyte - immunology
- Humans - administration & dosage
- Immunity, Humoral - immunology
- Immunity, Mucosal - immunology
- Immunoglobulin A - immunology
- Intestinal Mucosa - immunology
- Plasma Cells - immunology
- Find related publications in this database (Keywords)
- IgA antibodies
- plasma cell (PC)
- inflammation
- mucosal immunity
- autoimmunity
- gut-associated lymphoid tissues (GALT)