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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Rosenits, K; Keppler, SJ; Vucikuja, S; Aichele, P.
T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections.
Eur J Immunol. 2010; 40(12): 3450-7.
Doi: 10.1002/eji.201040743
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Keppler Selina Jessica
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- Abstract:
- Trogocytosis describes the transfer of surface determinants between immune cells and has been implicated in immune regulation. Most findings are based on in vitro studies since in vivo trogocytosis of immune cells is difficult to detect under physiological conditions. We used low frequencies of memory P14 T cells to demonstrate that T cells perform trogocytosis in vivo if in contact with APC pulsed with GP33-peptide or expressing the antigen endogenously. Furthermore, in vivo trogocytosis of T cells is demonstrated during infections with lymphocytic choriomeningitis virus and vaccinia virus. Trogocytosis-positive T cells revealed higher expression of activation marker and cytokines, showing a more activated phenotype compared to trogocytosis-negative T cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Adoptive Transfer - administration & dosage
- Animals - administration & dosage
- Antigen-Presenting Cells - immunology, metabolism, pathology
- Antigens, Surface - metabolism
- Antigens, Viral - immunology
- Arenaviridae Infections - immunology
- Cells, Cultured - administration & dosage
- Glycoproteins - immunology
- Lymphocyte Activation - administration & dosage
- Lymphocytic choriomeningitis virus - immunology, pathogenicity
- Membrane Fusion - immunology
- Mice - administration & dosage
- Mice, Inbred C57BL - administration & dosage
- Mice, Transgenic - administration & dosage
- Peptide Fragments - immunology
- Receptors, Antigen, T-Cell - genetics
- T-Lymphocytes - immunology, metabolism, pathology, virology
- Viral Proteins - immunology
- Find related publications in this database (Keywords)
- In vivo trogocytosis
- T cells
- Viral infection