Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ciccarelli, M; Pires, IF; Bauersachs, J; Bertrand, L; Beauloye, C; Dawson, D; Hamdani, N; Hilfiker-Kleiner, D; van, Laake, LW; Lezoualc'h, F; Linke, WA; Lunde, IG; Rainer, PP; Rispoli, A; Visco, V; Carrizzo, A; Ferro, MD; Stolfo, D; van, der, Velden, J; Zacchigna, S; Heymans, S; Thum, T; Tocchetti, CG.
Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function.
Cardiovasc Res. 2023; 119(14):2390-2404
Doi: 10.1093/cvr/cvad088
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Rainer Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Acute Disease - administration & dosage
- Prognosis - administration & dosage
- Heart Failure - diagnosis, genetics, therapy
- Chronic Disease - administration & dosage
- Risk Factors - administration & dosage
- Find related publications in this database (Keywords)
- Acute heart failure
- Phenotypes
- Trajectories
- Pre-clinical models
- Therapeutic management
- Scientific statement
- New strategies