Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reiter, C; Reiter, G; Kräuter, C; Kolesnik, E; Greiser, A; Scherr, D; Schmidt, A; Fuchsjäger, M; Reiter, U.
Impact of the evaluation method on 4D flow-derived diastolic transmitral and myocardial peak velocities: Comparison with echocardiography.
Eur J Radiol. 2024; 170: 111247
Doi: 10.1016/j.ejrad.2023.111247
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Reiter Clemens
- Reiter Ursula
- Co-Autor*innen der Med Uni Graz
- Fuchsjäger Michael
- Kolesnik Ewald
- Kräuter Corina
- Reiter Gert
- Scherr Daniel
- Schmidt Albrecht
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- Abstract:
- PURPOSE: To compare agreement of different evaluation methods of magnetic resonance (MR) 4D flow-derived diastolic transmitral and myocardial peak velocities as well as their ratios, using echocardiography as reference. METHODS: In this prospective study, 60 subjects without symptoms of cardiovascular disease underwent echocardiography and non-contrast 3 T MR 4D flow imaging of the heart. Early- (E) and late-diastolic (A) transmitral peak filling velocities were evaluated from 4D flow data using three different strategies: 1) at the mitral valve tips in short-axis orientation (SA-method), 2) between the mitral valve tips in 4-chamber orientation (4-chamber-method), and 3) as maximal velocities in the transmitral inflow volume (max-velocity-method). Septal, lateral and average early-diastolic myocardial peak velocities (e') were derived from the myocardial tissue in the vicinity of the mitral valve. 4D flow parameters were compared with echocardiography by correlation and Bland-Altman analysis. RESULTS: All 4D flow-derived E, A and E/A values correlated with echocardiography (r = 0.65-0.73, 0.75-0.83 and 0.74-0.86, respectively). While the SA- and 4-chamber-methods substantially underestimated E and A compared to echocardiography (p < 0.001), the max-velocity-method provided E (p = 0.13) and E/A (p = 0.07) without significant bias. Septal, lateral and average e' from 4D flow as well as the max-velocity-method-derived E/e' correlated with echocardiographic measurements (r = 0.64-0.81) and showed no significant bias (p = 0.26-0.54). CONCLUSION: MR 4D flow imaging allows precise and accurate evaluation of transmitral and myocardial peak velocities for characterization of LV diastolic function without significant bias to echocardiography, when transmitral velocities are assessed from the transmitral inflow volume. This enables the use of validated echocardiography threshold values.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Prospective Studies - administration & dosage
- Echocardiography - administration & dosage
- Myocardium - administration & dosage
- Mitral Valve - diagnostic imaging
- Magnetic Resonance Imaging - administration & dosage
- Blood Flow Velocity - administration & dosage
- Diastole - administration & dosage
- Find related publications in this database (Keywords)
- Magnetic resonance imaging
- Cardiovascular system
- Diagnostic imaging
- Heart function tests
- Validation study