Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Baron, J; Groschner, K; Tiapko, O.
Calcium transport and sensing in TRPC channels - New insights into a complex feedback regulation
CELL CALCIUM. 2023; 116: 102816
Doi: 10.1016/j.ceca.2023.102816
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Baron Jasmin
- Tiapko Oleksandra
- Co-Autor*innen der Med Uni Graz
- Groschner Klaus
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- Abstract:
- Canonical TRP (TRPC) channels are a still enigmatic family of signaling molecules with multimodal sensing features. These channels enable Ca2+ influx through the plasma membrane to control a diverse range of cellular functions. Based on both regulatory-and recently uncovered structural features, TRPC channels are considered to coordinate Ca2+ and other divalent cations not only within the permeation path but also at additional sensory sites. Analysis of TRPC structures by cryo-EM identified multiple regulatory ion binding pockets. With this review, we aim at an overview and a critical discussion of the current concepts of divalent sensing by TRPC channels.
- Find related publications in this database (Keywords)
- Ca 2+sensing
- TRPC channels
- Cellular regulation
- Divalent coordination