Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Scioscia, M; Siwetz, M; Robillard, PY; Brizzi, A; Huppertz, B.
Placenta and maternal endothelium during preeclampsia: Disruption of the glycocalyx explains increased inositol phosphoglycans and angiogenic factors in maternal blood.
J Reprod Immunol. 2023; 160:104161
Doi: 10.1016/j.jri.2023.104161
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
- Siwetz Monika
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- Abstract:
- The etiology of the pregnancy syndrome preeclampsia is still unclear, while most hypotheses center on the placenta as the major contributor of the syndrome. Especially changes of the placental metabolism, including the use of glucose to produce energy, are important features. As an example, inositol phosphoglycan P-type molecules, second messengers involved in the glucose metabolism of all cells, can be retrieved from maternal urine of preeclamptic women, even before the onset of clinical symptoms. Alterations in the placental metabolism may subsequently lead to negative effects on the plasma membrane of the placental syncytiotrophoblast. This in turn may have deleterious effects on the glycocalyx of this layer and a disruption of this layer in all types of preeclampsia. The interruption of the glycocalyx in preeclampsia may result in changes of inositol phosphoglycan P-type signaling pathways and the release of these molecules as well as the release of soluble receptors such as sFlt-1 and sEndoglin. The release of placental factors later affects the maternal endothelium and disrupts the endothelial glycocalyx as well. This in turn may pave the way for edema, endothelial dysfunction, coagulation, all typical symptoms of preeclampsia.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Pregnancy - administration & dosage
- Humans - administration & dosage
- Placenta - metabolism
- Pre-Eclampsia - metabolism
- Glycocalyx - metabolism
- Endothelium - administration & dosage
- Vascular Endothelial Growth Factor Receptor-1 - metabolism
- Find related publications in this database (Keywords)
- Pregnancy
- Preeclampsia
- P-IPG
- Syndecan-1
- Warburg metabolism