Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leis, HJ; Gleispach, H; Windischhofer, W.
Preparation of Deuterated Diclofenac for Use as an Internal Standard in Quantitative Measurement by Gas-Chromatography Negative-Ion Chemical-Ionization Mass-Spectrometry
RAPID COMMUN MASS SPECTROM 1996 10: 1605-1606.
Doi: 10.1002/(SICI)1097-0231(199610)10:13<1605::AID-RCM684>3.3.CO;2-G
Web of Science
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leis Hans-Joerg
- Co-Autor*innen der Med Uni Graz
- Windischhofer Werner
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A procedure for the preparation of deuterated diclofenac is described, The resulting d(5)-diclofenac was used as an internal standard for quantitative measurement of the drug. The benefits of deuteration versus oxygen-18 labeling are demonstrated. Enhanced stability of the isotope label resulted in greater flexibility in sample handling during the work-up steps of plasma samples.