Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Glachs, L; Embacher, S; Berghold, A; Wildner, B; Michelitsch, M; Tscherne, A; Wedrich, A; Posch-Pertl, L.
Treatment of myopic choroidal neovascularization: a network meta-analysis and review.
Graefes Arch Clin Exp Ophthalmol. 2024; 262(6):1693-1722
Doi: 10.1007/s00417-023-06271-2
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- Führende Autor*innen der Med Uni Graz
- Glachs Laura
- Posch-Pertl Laura
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Embacher Stefan
- Michelitsch Monja
- Wedrich Andreas
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- Abstract:
- PURPOSE: This is, to our knowledge, the first network meta-analysis aiming to compare all treatment modalities for myopic choroidal neovascularization (CNV). METHODS: After the electronic databases were searched, two independent reviewers screened titles, abstracts, full-texts, and extracted information. Primary endpoints were change in visual outcome and central retinal thickness. We used a network meta-analysis to compare treatment outcomes in the early (≤ 6 months) and late (> 6 months) phase. RESULTS: We included 34 studies (2,098 eyes) in our network meta-analysis. In the early phase, the use of anti-VEGF led to a gain of 14.1 letters (95% CI, 10.8-17.4) compared to untreated patients (p < 0.0001), 12.1 letters (95% CI, 8.3-15.8) to photodynamic therapy (PDT) (p < 0.0001), 7.5 (95% CI, 1.2-13.8) letters to intravitreal triamcinolone acetonide (TCA) (p = 0.019), and - 2.9 letters (95% CI, - 6.0-0.2) to the combination of anti-VEGF and PDT (p = 0.065). In the later phase, these results were largely maintained. There were no significant differences in visual outcomes between patients treated with 1 + PRN and 3 + PRN. However, the 1 + PRN group received 1.8 (SD 1.3), while the 3 + PRN group received 3.2 (SD 0.9) injections within 12 months (p < 0.0001). CONCLUSION: This network meta-analysis confirms that anti-VEGF is the most effective treatment for myopic CNV using the 1 + PRN treatment strategy.
- Find related publications in this database (using NLM MeSH Indexing)
- Choroidal Neovascularization - drug therapy, diagnosis, physiopathology
- Humans - administration & dosage
- Visual Acuity - administration & dosage
- Angiogenesis Inhibitors - therapeutic use, administration & dosage
- Myopia, Degenerative - complications, physiopathology, diagnosis
- Intravitreal Injections - administration & dosage
- Photochemotherapy - methods
- Network Meta-Analysis - administration & dosage
- Vascular Endothelial Growth Factor A - antagonists & inhibitors
- Tomography, Optical Coherence - methods
- Find related publications in this database (Keywords)
- Aflibercept
- Anti-VEGF
- Bevacizumab
- Choroidal neovascularization
- Conbercept
- Myopia
- Myopic CNV
- Photodynamic therapy
- Ranibizumab