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SHR Neuro Cancer Cardio Lipid Metab Microb

Yosipovitch, G; Lio, PA; Rosmarin, D; Serra-Baldrich, E; Legat, FJ; Casillas, M; Pierce, E; Liu, Z; Sun, L; Elmaraghy, H; Ständer, S.
Lebrikizumab improved itch and reduced the extent of itch interference on sleep in patients with moderate-to-severe atopic dermatitis: two randomized, placebo-controlled, phase III trials.
Br J Dermatol. 2024; 190(2): 289-291. Doi: 10.1093/bjd/ljad435
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Co-authors Med Uni Graz: Legat Franz
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Abstract:: Itch and sleep loss due to itch are prevalent symptoms of moderate-to-severe atopic dermatitis, significantly impairing patients' quality of life and wellbeing. First-line topical therapy is insufficient for most patients and there is an unmet need for effective treatments that provide symptom relief and quality of life improvement. In two randomized, placebo-controlled, phase III trials, significantly more patients treated with the novel monoclonal antibody lebrikizumab had >= 3-point improvement in Pruritus Numeric Rating Scale by week 16 vs. patients treated with placebo. In addition, significantly more patients treated with lebrikizumab achieved >= 1-point improvement in Sleep-Loss Scale score by week 16 vs. placebo. Onset of itch relief was rapid, occurring within the first few days of treatment.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Dermatitis, Atopic - administration & dosage; Pruritus - administration & dosage; Antibodies, Monoclonal - administration & dosage; Sleep - administration & dosage; Severity of Illness Index - administration & dosage; Double-Blind Method - administration & dosage; Treatment Outcome - administration & dosage