Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schnoegl, D; Hiesinger, A; Huntington, ND; Gotthardt, D.
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.
Curr Opin Immunol. 2023; 85:102397
Doi: 10.1016/j.coi.2023.102397
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schnögl Diana
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- Abstract:
- The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are central to generate immunity to pathogens or malignancies. Here, we provide an overview of the current understanding of how AP-1 TFs regulate cytotoxic lymphocytes.