Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sokolowski, A; Theisen, K; Arefnia, B; Payer, M; Lorenzoni, M; Sokolowski, A.
A randomized clinical trial of phycogenic materials for sinus grafting with hydroxyapatite versus biphasic calcium phosphate: 2 years clinical outcomes.
Clin Oral Implants Res. 2024; 35(2):155-166
Doi: 10.1111/clr.14209
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Sokolowski Alwin
- Sokolowski Armin
- Co-Autor*innen der Med Uni Graz
- Arefnia Behrouz
- Lorenzoni Martin
- Payer Michael
- Theisen Kerstin
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- Abstract:
- OBJECTIVES: To assess in a prospective randomized trial two phycogenic bone substitutes-biphasic calcium phosphate (BCP) versus almost pure hydroxyapatite (HA)-for their volume stability and clinical implications after sinus floor elevation (SFE). MATERIALS AND METHODS: Twenty patients requiring lateral-window SFE 6 months prior to implant surgery were randomized to a BCP or HA group. As primary outcome, the grafts were analyzed for volume stability, using four cone-beam computed tomography scans obtained immediately/6/12/24 months after SFE. Secondary outcomes were implant survivval, success, periotest values, oral-health-related quality of life (OHIP-G14), and pain (VAS). RESULTS: Kolmogorov-Smirnov goodness-of-fit test revealed normal distribution of samples (p = .200). At 6/12/24 months, the augmented volumes decreased to 96/92/90% (HA) or 99/96/96% (BCP). Volume changes were significantly a factor of time (p < .001; generalized linear model with repeated measures) and reached significantly lower values in HA group (p = .018). Significant intergroup difference in volume losses was notable at 24 months (p = .021; t-test for independent samples). Periotest values decreased from -3/-4.1 (HA/BCP) after implant placement to -6.3/-4.5 (HA/BCP) after 6 months. OHIP scores diverged at 2 months (HA: 9.5; BCP: 5.2) and largely resolved by 24 months (HA: 1.3; BCP: 1.9). VAS scores were comparable, 2.2 at 1 week after SFE being their highest mean level. CONCLUSIONS: After 2 years, both groups experienced no biological or technical complications, demonstrating a consistent healing trajectory without notable symptoms. Although no significant differences were observed in implant stability and survival, BCP demonstrated higher volume stability than HA.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Durapatite - therapeutic use
- Sinus Floor Augmentation - methods
- Prospective Studies - administration & dosage
- Quality of Life - administration & dosage
- Hydroxyapatites - therapeutic use
- Bone Substitutes - therapeutic use
- Maxillary Sinus - surgery
- Find related publications in this database (Keywords)
- biomaterials
- bone implant interactions
- bone regeneration
- bone substitutes
- clinical research
- clinical trials
- CT imaging
- sinus floor elevation