Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Späth, Z; Tmava-Berisha, A; Fellendorf, FT; Stross, T; Maget, A; Platzer, M; Bengesser, SA; Häussl, A; Zwigl, I; Birner, A; Queissner, R; Stix, K; Wels, L; Lenger, M; Dalkner, N; Zelzer, S; Herrmann, M; Reininghaus, EZ.
Vitamin D Status in Bipolar Disorder.
Nutrients. 2023; 15(22):
Doi: 10.3390/nu15224752
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- Führende Autor*innen der Med Uni Graz
- Tmava-Berisha Adelina
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Dalkner Nina
- Fellendorf Frederike
- Häussl Alfred Alois
- Herrmann Markus
- Lenger Melanie
- Maget Alexander
- Platzer Martina
- Queissner Robert
- Reininghaus Eva
- Stix Katharina
- Stross Tatjana Maria
- Wels Linda
- Zelzer Sieglinde
- Zwigl Ina
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- Abstract:
- Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2D, and the vitamin D metabolite ratio (VMR) in BD and correlated the results with clinical affective symptomatology and functionality. The inactive precursor 25(OH)D, and its principal catabolite 24,25(OH)2D, were measured simultaneously with a validated liquid chromatography-tandem mass spectrometry method in 170 BD outpatients and 138 healthy controls. VMR was calculated as follows: VMR = 100×(24,25(OH)2D/25(OH)D). The psychometric assessment comprised: Beck Depression Inventory-II, Hamilton Depression Rating Scale, Young Mania Rating Scale, Global Assessment of Functioning, and number of suicide attempts. We did not find a significant difference between patients and controls in the concentrations of 25(OH)D and 24,25(OH)2D. Additionally, the VMR was comparable in both groups. The calculations for the clinical parameters showed a negative correlation between the Young Mania Rating Scale and 24,25(OH)2D (r = -0.154, p = 0.040), as well as the Young Mania Rating Scale and the VMR (r = -0.238, p = 0.015). Based on the small effect size and the predominantly euthymic sample, further exploration in individuals with manic symptoms would be needed to confirm this association. In addition, long-term clinical markers and an assessment in different phases of the disease may provide additional insights.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Vitamin D - administration & dosage
- Bipolar Disorder - psychology
- Cross-Sectional Studies - administration & dosage
- Mania - administration & dosage
- Vitamins - administration & dosage
- Find related publications in this database (Keywords)
- bipolar disorder
- vitamin D metabolism
- functional vitamin D deficiency
- 25(OH)D
- 24,25(OH)(2)D
- VMR