Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kerestes, R; Laansma, MA; Owens-Walton, C; Perry, A; van, Heese, EM; Al-Bachari, S; Anderson, TJ; Assogna, F; Aventurato, ÍK; van, Balkom, TD; Berendse, HW; van, den, Berg, KRE; Betts, R; Brioschi, R; Carr, J; Cendes, F; Clark, LR; Dalrymple-Alford, JC; Dirkx, MF; Druzgal, J; Durrant, H; Emsley, HCA; Garraux, G; Haroon, HA; Helmich, RC; van, den, Heuvel, OA; João, RB; Johansson, ME; Khachatryan, SG; Lochner, C; McMillan, CT; Melzer, TR; Mosley, PE; Newman, B; Opriessnig, P; Parkes, LM; Pellicano, C; Piras, F; Pitcher, TL; Poston, KL; Rango, M; Roos, A; Rummel, C; Schmidt, R; Schwingenschuh, P; Silva, LS; Smith, V; Squarcina, L; Stein, DJ; Tavadyan, Z; Tsai, CC; Vecchio, D; Vriend, C; Wang, JJ; Wiest, R; Yasuda, CL; Young, CB; Jahanshad, N; Thompson, PM; van, der, Werf, YD; Harding, IH, , ENIGMA-Parkinson's, Study.
Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.
Mov Disord. 2023; 38(12):2269-2281
Doi: 10.1002/mds.29611
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- Co-Autor*innen der Med Uni Graz
- Opriessnig Peter
- Schmidt Reinhold
- Schwingenschuh Petra
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- Abstract:
- BACKGROUND: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated. OBJECTIVE: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group. METHODS: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated. RESULTS: Overall, people with PD had a regionally smaller posterior lobe (dmax = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (dmax = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (dmax = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17). CONCLUSIONS: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Parkinson Disease - complications
- Cross-Sectional Studies - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Cerebellum - administration & dosage
- Brain - administration & dosage
- Find related publications in this database (Keywords)
- cerebellum
- disease staging
- MRI
- Parkinson's disease