Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Franthal, S; Khalil, M; Kern, D; Gattermeyer, L; Buchmann, A; Katschnig-Winter, P; Kögl, M; Demjaha, R; Tafrali, C; Hofer, E; Schmidt, R; Schwingenschuh, P.
Elevated serum neurofilament light chain protein in patients with essential tremor.
Eur J Neurol. 2024; 31(2):e16143
Doi: 10.1111/ene.16143
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- Führende Autor*innen der Med Uni Graz
- Franthal Sebastian Othmar
- Schwingenschuh Petra
- Co-Autor*innen der Med Uni Graz
- Buchmann Arabella
- Demjaha Rina
- Gattermeyer-Kell Lukas
- Hofer Edith
- Katschnig-Winter Petra
- Kern Daniela
- Khalil Michael
- Kögl Mariella Waltraud
- Schmidt Reinhold
- Tafrali Cansu
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- Abstract:
- BACKGROUND AND PURPOSE: Quantification of neurofilament light chain protein in serum (sNfL) enables the neuro-axonal damage in peripheral blood to be reliably assessed and monitored. There is a long-standing debate whether essential tremor represents a 'benign' tremor syndrome or whether it is linked to neurodegeneration. This study aims to investigate sNfL concentrations in essential tremor compared to healthy controls (cross-sectionally and longitudinally) and to assess whether sNfL is associated with motor and nonmotor markers of disease progression. METHODS: Data of patients with essential tremor from our prospective registry on movement disorders (PROMOVE) were retrospectively analysed. Age-, sex- and body-mass-index-matched healthy controls were recruited from an ongoing community-dwelling aging cohort. sNfL was quantified by an ultra-sensitive single molecule array (Simoa). All participants underwent detailed clinical examination at baseline and after approximately 5 years of follow-up. RESULTS: Thirty-seven patients with clinically diagnosed essential tremor were included and 37 controls. The essential tremor group showed significantly higher sNfL levels compared to healthy controls at baseline and follow-up. sNfL levels increased over time in both groups, and the slope of sNfL increase was similar in the essential tremor and healthy control groups. Comparing patients with a disease duration under 5 years to those with a longer disease duration, the former group had a significantly greater increase of sNfL over time, which strongly correlated to worsening of tremor and cognition. CONCLUSION: Our findings indicate that neurodegeneration, possibly happening at an early disease stage, might play a role in the pathophysiology of essential tremor.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Biomarkers - administration & dosage
- Retrospective Studies - administration & dosage
- Essential Tremor - administration & dosage
- Tremor - administration & dosage
- Intermediate Filaments - administration & dosage
- Neurofilament Proteins - administration & dosage
- Multiple Sclerosis - administration & dosage
- Find related publications in this database (Keywords)
- essential tremor
- neurodegeneration
- neurofilament light chain protein
- pathophysiology
- sNfL
- tremor