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Wolfsberger, CH; Avian, A; Schwaberger, B; Pichler, G; Wolf, M; Urlesberger, B.
Precision and normal values of cerebral blood volume in preterm neonates using time-resolved near-infrared spectroscopy.
Acta Paediatr. 2024; 113(4):677-683
Doi: 10.1111/apa.17040
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Wolfsberger Christina Helene
- Co-authors Med Uni Graz
- Avian Alexander
- Pichler Gerhard
- Schwaberger Bernhard
- Urlesberger Berndt
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- Abstract:
- AIM: To investigate cerebral blood volume (CBV) in preterm neonates using time-resolved near-infrared spectroscopy. METHODS: In this prospective observational study, time-resolved near-infrared spectroscopy measurements of CBV using tNIRS-1 were performed in 70 preterm neonates. For measurements, a sensor was placed for a duration of 1 min, followed by four further reapplications of the sensor, overall five measurements. RESULTS: In this study, 70 preterm neonates with a mean ± SD gestational age of 33.4 ± 1.7 weeks and a birthweight of 1931 ± 398 g were included with a postnatal age of 4.7 ± 2.0 days. Altogether, 2383 CBV values were obtained with an overall mean of 1.85 ± 0.30 mL/100 g brain. A total of 95% of the measured CBV values varied in a range from -0.31 to 0.33 from the overall individual mean. Taking the deviation of the mean of each single application for each patient, this range reduced from -0.07 to 0.07. The precision of the measurement defined as within-variation in CBV was 0.24 mL/100 g brain. CONCLUSION: The overall mean CBV in stable preterm neonates was 1.85 ± 0.30 mL/100 g brain. The within-variation in CBV was 0.24 mL/100 g brain. Based on the precision obtained by our data, CBV of 1.85 ± 0.30 mL/100 g brain may be assumed as normal value for this cohort.
- Find related publications in this database (using NLM MeSH Indexing)
- Infant, Newborn - administration & dosage
- Humans - administration & dosage
- Infant - administration & dosage
- Spectroscopy, Near-Infrared - administration & dosage
- Cerebral Blood Volume - administration & dosage
- Reference Values - administration & dosage
- Cerebrovascular Circulation - administration & dosage
- Brain - diagnostic imaging
- Oxygen - administration & dosage
- Find related publications in this database (Keywords)
- cerebral blood volume
- normal value
- precision
- preterm neonates
- time-resolved NIRS