Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneditz, D; Hofmann, P; Krenn, S; Waller, M; Mussnig, S; Hecking, M.
Day-to-day variability in euvolemic body mass.
Ren Fail. 2023; 45(2): 2273421
Doi: 10.1080/0886022X.2023.2273421
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- Führende Autor*innen der Med Uni Graz
- Schneditz Daniel
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- Abstract:
- Short-term variability in body mass is a common, everyday phenomenon; however, data on body mass variability are scarce. While the physiological variability of body mass is negligible in healthy individuals, it could have implications for therapy in patients with impaired volume homeostasis, for example, patients with kidney failure undergoing kidney replacement therapy. We analyzed a long-term dataset comprising 9521 days of standardized body mass measurements from one healthy male individual and assessed the variability in body mass as a positive or negative relative difference in body mass measured on subsequent days. The average and median relative differences were zero, with a standard deviation (SD) of 0.53% for the one-day interval, increasing to 0.69% for the 7-day interval, and this variability was constant throughout the observation period. A body mass variability of approximately 0.6% (±450 mL in a 75-kg patient) should be taken into consideration when weight-dependent treatment prescriptions, e.g. the ultrafiltration rates in patients on hemodialysis, are being set. Consequently, a "soft target weight", considering the longitudinal variation of volume markers, such as body mass, might improve treatment quality.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Kidney Failure, Chronic - therapy, etiology
- Renal Dialysis - adverse effects
- Ultrafiltration - administration & dosage
- Body Weight - administration & dosage
- Find related publications in this database (Keywords)
- Dry weight
- target weight
- volume control
- ultrafiltration
- prescription
- hemodialysis