Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Garcia-Garcia, HM; Waksman, R; Melaku, GD; Garg, M; Beyene, S; Wlodarczak, A; Kerai, A; Levine, MB; van, der, Schaaf, RJ; Torzewski, J; Ferdinande, B; Escaned, J; Iglesias, JF; Bennett, J; Toth, GG; Joner, M; Toelg, R; Wiemer, M; Olivecrona, G; Vermeersch, P; Haude, M.
Temporal Changes in Coronary Plaque as Assessed by an Artificial Intelligence Based Optical Coherence Tomography: From the First-in-Human Trial on DREAMS 3G Scaffold.
Eur Heart J Cardiovasc Imaging. 2023; Doi: 10.1093/ehjci/jead299
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Toth-Gayor Gabor
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: AIMS: To assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6-month (6 M), and 12-month (12 M) follow-up. METHODS AND RESULTS: A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 months. OCTPlus software uses artificial intelligence to assess composition (i.e., lipid, calcium, fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention (PCI) and 12 M, were grouped into 3 terciles. Patients with larger MLA differences at 12 M (p 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both p < 0.001, between the pre-DREAMS 3G OCT and the 6 M and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 M and 12 M follow-up, both p < 0.001. CONCLUSIONS: The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 M and 12 M. Following the implantation of DREAMS 3G, favorable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue.
Find related publications in this database (Keywords): optical coherence tomography; minimum lumen area; percutaneous coronary intervention; drug-eluting stent; bioresorbable stent; de novo coronary lesion