Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Kasteler, R; Otth, M; Halbeisen, FS; Mader, L; Singer, F; Rössler, J; von, der, Weid, NX; Ansari, M; Kuehni, CE.
Longitudinal assessment of lung function in Swiss childhood cancer survivors-A multicenter cohort study.
Pediatr Pulmonol. 2024; 59(1):169-180
Doi: 10.1002/ppul.26738
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Singer Florian
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- Abstract:
- OBJECTIVE: Childhood cancer survivors are at risk for pulmonary morbidity due to exposure to lung-toxic treatments, including specific chemotherapeutics, radiotherapy, and surgery. Longitudinal data on lung function and its change over time are scarce. We investigated lung function trajectories in survivors over time and the association with lung-toxic treatments. METHODS: This retrospective, multicenter cohort study included Swiss survivors diagnosed between 1990 and 2013 and exposed to lung-toxic chemotherapeutics or thoracic radiotherapy. Pulmonary function tests (PFTs), including forced expiration volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, total lung capacity, and diffusion capacity of the lung for carbon monoxide, were obtained from hospital charts. We calculated z-scores and percentage predicted, described lung function over time, and determined risk factors for change in FEV1 and FVC using multivariable linear regression. RESULTS: We included 790 PFTs from 183 survivors, with a median age of 12 years at diagnosis and 5.5 years of follow-up. Most common diagnosis was lymphoma (55%). Half (49%) of survivors had at least one abnormal pulmonary function parameter, mainly restrictive (22%). Trajectories of FEV1 and FVC started at z-scores of -1.5 at diagnosis and remained low throughout follow-up. Survivors treated with thoracic surgery started particularly low, with an FEV1 of -1.08 z-scores (-2.02 to -0.15) and an FVC of -1.42 z-scores (-2.27 to -0.57) compared to those without surgery. CONCLUSION: Reduced pulmonary function was frequent but mainly of mild to moderate severity. Nevertheless, more research and long-term surveillance of this vulnerable population is needed.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Child - administration & dosage
- Cancer Survivors - administration & dosage
- Cohort Studies - administration & dosage
- Retrospective Studies - administration & dosage
- Switzerland - epidemiology
- Neoplasms - administration & dosage
- Lung - administration & dosage
- Vital Capacity - administration & dosage
- Forced Expiratory Volume - administration & dosage
- Find related publications in this database (Keywords)
- childhood cancer
- cohort study
- diffusing capacity
- lung volume measurements
- spirometry