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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Leser, B; Dalkner, N; Tmava-Berisha, A; Fellendorf, FT; Unterrainer, HF; Stross, T; Maget, A; Platzer, M; Bengesser, SA; Häussl, A; Zwigl, I; Birner, A; Queissner, R; Stix, K; Wels, L; Schönthaler, EMD; Lenger, M; Schwerdtfeger, AR; Zelzer, S; Herrmann, M; Reininghaus, EZ.
The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls.
Nutrients. 2023; 15(19): 4111
Doi: 10.3390/nu15194111
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- Leading authors Med Uni Graz
- Dalkner Nina
- Co-authors Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Fellendorf Frederike
- Häussl Alfred Alois
- Herrmann Markus
- Lenger Melanie
- Maget Alexander
- Platzer Martina
- Queissner Robert
- Reininghaus Eva
- Schönthaler Elena
- Stix Katharina
- Stross Tatjana Maria
- Tmava-Berisha Adelina
- Unterrainer Human-Friedrich
- Wels Linda
- Zelzer Sieglinde
- Zwigl Ina
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- Abstract:
- Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains "attention", "memory", or "executive function" in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study's cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment.
- Find related publications in this database (Keywords)
- bipolar disorder
- vitamin D
- functional vitamin D deficiency
- 25(OH)D
- 24,25(OH)2D
- VMR