Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weber, M; Strohscheer, I; Samonigg, H; Huber, C.
Palliative sedation--an alternative to euthanasia in intractable pain at the end of life?
Med Klin (Munich). 2005; 100(5): 292-298.
Doi: 10.1007/s00063-005-1038-9
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Samonigg Hellmut
- Strohscheer Imke
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- Abstract:
- A typical Headache and Facial Pain as a Result of Hypertrophic Pachymeningitis in C-ANCA-Positive Wegener's Granulomatosis 0 Background: Wegener's granulomatosis (WG) is a systemic vasculitis involving the nervous system in 20-54% of cases; lesions of peripheral nerves are commonest, while manifestation in the central nervous system (CNS) is rarer. Focal hypertrophic pachymeningitis is a very rare complication of WG. This inflammatory thickening and fibrosis of the dura mater is always associated with headaches, whereas cranial nerve lesions, cerebellar symptoms or epileptic seizures occur more rarely. Case Report: A 67-year-old patient, in whom WG had been diagnosed 2 years earlier and who had been treated with immunosuppressants since then, complained of continuous severe, mainly left-sided headache and facial pain for weeks. Cranial MRI showed thickening of the left tentorium cerebelli with obvious contrast enhancement and led to the diagnosis of hypertrophic pachymeningitis. The inflammatory parameters and the C-ANCA (antineutrophil cytoplasmic antibodies) in the serum were raised and CANCA were detectable in the cerebrospinal fluid. The headaches subsided with several days of intravenous high-dose corticosteroids and a simultaneous increase in the immunosuppressive basic medication. On a follow-up MRI after 3 months, the magnetic resonance changes were less apparent, i.e., the hypertrophic pachymeningitis was resolving; C-ANCA were now no longer detectable in the cerebrospinal fluid. Conclusion: With newly occurring, unusually severe and persistent head aches in the presence of WG, the very rare complication of hypertrophic pachymeningitis should be considered.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Conscious Sedation - ethics
- Cross-Cultural Comparison - ethics
- Ethics, Medical - ethics
- Euthanasia, Active - ethics
- Germany - ethics
- Humans - ethics
- Male - ethics
- Midazolam - ethics
- Pain, Intractable - therapy
- Palliative Care - ethics
- Right to Die - ethics
- Risk Assessment - ethics
- Stress, Psychological - ethics
- Terminal Care - ethics
- Find related publications in this database (Keywords)
- Wegener's granulomatosis
- hypertrophic pachymeningitis
- atypical headache
- C-ANCA
- cerebrospinal fluid