Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Feuerstein, A; Schoenrath, F; Belyavskiy, E; Knierim, J; Friede, T; Placzek, M; Bach, D; Pieske-Kraigher, E; Herrmann-Lingen, C; Westenfeld, R; Roden, M; Rybczynski, M; Verheyen, N; Dörr, M; von, Haehling, S; Störk, S; Halle, M; Falk, V; Pieske, B; Edelmann, F.
Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial (Ex-VAD trial).
Eur J Heart Fail. 2023;
Doi: 10.1002/ejhf.3032
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Bach Doris
- Belyavskiy Evgeny
- Pieske Burkert Mathias
- Verheyen Nicolas Dominik
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- Abstract:
- AIMS: Small studies and observations suggested that exercise training may improve peak oxygen consumption (peakVO2 ) in patients with advanced heart failure and left ventricular assist device (LVAD). We investigated whether in this patient group a supervised exercise training can improve exercise capacity. METHODS AND RESULTS: In this multicentre, prospective, randomized, controlled trial, patients with stable heart failure and LVAD were randomly assigned (2:1) to 12 weeks of supervised exercise training or usual care, with 12 weeks of follow-up. The primary endpoint was the change in peakVO2 after 12 weeks (51 patients provided a power of 90% with an expected group difference in peakVO2 of 3 ml/kg/min). Secondary endpoints included changes in submaximal exercise capacity and quality of life. Among 64 patients enrolled (97% male, mean age 56 years), 54 were included in the analysis. Mean difference in the change of peakVO2 after 12 weeks was 0.826 ml/min/kg (95% confidence interval [CI] -0.37, 2.03; p = 0.183). There was a positive effect of exercise training on 6-min walk distance with a mean increase in the intervention group by 43.4 m (95% CI 16.9, 69.9; p = 0.0024), and on the Kansas City Cardiomyopathy Questionnaire physical domain score (mean 14.3, 95% CI 3.7, 24.9; p = 0.0124), both after 12 weeks. The overall adherence was high (71%), and there were no differences in adverse events between groups. CONCLUSION: In patients with advanced heart failure and LVAD, 12 weeks of exercise training did not improve peakVO2 but demonstrated positive effects on submaximal exercise capacity and physical quality of life.
- Find related publications in this database (Keywords)
- Advanced heart failure
- Left ventricular assist device
- Supervised exercise training
- Exercise capacity