Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Michaelis, S; Zelzer, S; Schneider, C; Schnedl, WJ; Baranyi, A; Meinitzer, A; Herrmann, M; Enko, D.
The possible role of quinolinic acid as a predictive marker in patients with SARS-CoV-2.
Clin Chim Acta. 2023; 550:117583
Doi: 10.1016/j.cca.2023.117583
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Baranyi Andreas
- Enko Dietmar
- Herrmann Markus
- Meinitzer Andreas
- Schnedl Wolfgang
- Zelzer Sieglinde
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND AND AIMS: Quinolinic acid (QA) is a metabolite of the kynurenine pathway, which is activated by inflammatory stimuli during viral infection. We investigated the role of QA in patients infected with SARS-CoV-2, particularly its prognostic value for survival. METHODS: Overall, 104 unvaccinated inpatients were included, divided into a survival (N = 80) and a deceased group (N = 24). Plasma levels of tryptophan, kynurenine, QA, C-reactive protein (CRP) and procalcitonin (PCT) were measured on admission and after seven days. The QA/TRP ratio and the relative differences between the measurements for QA (QA-Diff) and QA/TRP (Diff-QA/TRP) were calculated. RESULTS: Among the kynurenine pathway markers, QA-Diff showed the highest discriminatory power for the survival prognosis (Youden index 0.467, cut-off -1.3 %, AUC 0.733, p < 0.001, sensitivity 0.79, specificity 0.675). Among the inflammatory markers, CRP showed the highest discriminatory power (Youden index 0.533, cut-off 25.0 mg/L, AUC 0.794, p < 0.001, sensitivity 0.958, specificity 0.575). A significant correlation between QA and PCT was found on admission and after one week (Spearman's rho 0.455 and 0.539, all p-values < 0.001). CONCLUSIONS: QA may serve as prognostic marker for survival in patients with SARS-CoV-2. The repeated measurements during the first week of the disease may enhance the prognostic power.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Kynurenine - metabolism
- Quinolinic Acid - metabolism
- SARS-CoV-2 - administration & dosage
- COVID-19 - diagnosis
- Tryptophan - metabolism
- C-Reactive Protein - metabolism
- Procalcitonin - administration & dosage
- Find related publications in this database (Keywords)
- Quinolinic acid
- SARS-CoV-2
- Kynurenine pathway