Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Poelzl, S; Rieger, J; Zatloukal, K; Augl, S; Stummer, M; Hinterer, A; Kittinger, C.
Inactivation of Bacteriophage ɸ6 and SARS-CoV-2 in Antimicrobial Surface Tests.
Viruses. 2023; 15(9): 1833
Doi: 10.3390/v15091833
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- Führende Autor*innen der Med Uni Graz
- Kittinger Clemens
- Pölzl Sabine
- Co-Autor*innen der Med Uni Graz
- Kircher Julia
- Zatloukal Kurt
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- Abstract:
- Due to the COVID-19 pandemic, researchers have focused on new preventive measures to limit the spread of SARS-CoV-2. One promising application is the usage of antimicrobial materials on often-touched surfaces to reduce the load of infectious virus particles. Since tests with in vitro-propagated SARS-CoV-2 require biosafety level 3 (BSL-3) laboratories with limited capacities and high costs, experiments with an appropriate surrogate like the bacteriophage ɸ6 are preferred in most studies. The aim of this study was to compare ɸ6 and SARS-CoV-2 within antiviral surface tests. Different concentrations of copper coatings on polyethylene terephthalate (PET) were used to determine their neutralizing activity against ɸ6 and SARS-CoV-2. The incubation on the different specimens led to similar inactivation of both SARS-CoV-2 and ɸ6. After 24 h, no infectious virus particles were evident on any of the tested samples. Shorter incubation periods on specimens with high copper concentrations also showed a complete inactivation. In contrast, the uncoated PET foils resulted only in a negligible reduced inactivation during the one-hour incubation. The similar reduction rate for ɸ6 and SARS-CoV-2 in our experiments provide further evidence that the bacteriophage ɸ6 is an adequate model organism for SARS-CoV-2 for this type of testing.
- Find related publications in this database (Keywords)
- bacteriophage
- ɸ6
- SARS-CoV-2
- antimicrobial surface